InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rad23a

Summary

InnateDB Gene

IDBG-174863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad23a

Gene Name

RAD23a homolog (S. cerevisiae)

Synonyms

2310040P19Rik; AL024030; HR23A; mHR23A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003813

Encoded Proteins

IDBP-174865

RAD23a homolog (S. cerevisiae)

IDBP-261700

RAD23a homolog (S. cerevisiae)

IDBP-536265

RAD23a homolog (S. cerevisiae)

IDBP-533386

RAD23a homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23357418

RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.

InnateDB Annotation from Orthologs

Summary

PMID 23357418

[Homo sapiens] RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179262:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:84834019-84840665

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003911	ENSMUSP00000003911
ENSMUST00000109761	ENSMUSP00000105383
ENSMUST00000144675	ENSMUSP00000114431
ENSMUST00000128035	ENSMUSP00000115664
ENSMUST00000134395
ENSMUST00000144994
ENSMUST00000125711

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000179262

View Gene Order

ENSBTAG00000015116

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03420

Nucleotide excision repair pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03420

Nucleotide excision repair pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_009010 XM_006530774

OMIM

CCDS

CCDS40414

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas