Version 5.4
Bos taurus Gene: SLC4A4
Summary
InnateDB Gene IDBG-642956.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC4A4
Gene Name electrogenic sodium bicarbonate cotransporter 1
Synonyms NBC1
Species Bos taurus
Ensembl Gene ENSBTAG00000002348
Encoded Proteins
IDBP-695473
electrogenic sodium bicarbonate cotransporter 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080493:
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:88182303-88541046
Strand Forward strand
Band
Transcripts
ENSBTAT00000003032 ENSBTAP00000003032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0005515 protein binding
GO:0008509 anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0015701 bicarbonate transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000080493
View Gene Order
ENSMUSG00000060961
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19298
Bicarbonate transporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_229600
Bicarbonate transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04972
Pancreatic secretion pathway
hsa04976
Bile secretion pathway
mmu04976
Bile secretion pathway
mmu04964
Proximal tubule bicarbonate reclamation pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.7156
RefSeq NM_174605 XM_005208064 XM_005208066 XM_005208069
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca