InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC12A5

Summary

InnateDB Gene

IDBG-642995.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A5

Gene Name

solute carrier family 12 member 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014179

Encoded Proteins

IDBP-695551

SLC12A5 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124140:
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:75487262-75516206

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018852

ENSBTAP00000018852

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0035264	multicellular organism growth
GO:0040040	thermosensory behavior
GO:0042493	response to drug
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport