Version 5.4
Homo sapiens Gene: SLC12A5
Summary
InnateDB Gene IDBG-78814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A5
Gene Name solute carrier family 12 (potassium/chloride transporter), member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124140
Encoded Proteins
IDBP-78816
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-78818
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-377046
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-591624
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-807636
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-807642
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-807643
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-807658
solute carrier family 12 (potassium/chloride transporter), member 5
IDBP-807660
solute carrier family 12 (potassium/chloride transporter), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:46021717-46060150
Strand Forward strand
Band q13.12
Transcripts
ENST00000372315 ENSP00000361389
ENST00000243964 ENSP00000243964
ENST00000454036 ENSP00000387694
ENST00000539566 ENSP00000446091
ENST00000608944 ENSP00000476885
ENST00000608594
ENST00000616201 ENSP00000484585
ENST00000622711 ENSP00000481981
ENST00000616933 ENSP00000477569
ENST00000616202 ENSP00000478369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006821 chloride transport
GO:0006873 cellular ion homeostasis
GO:0007268 synaptic transmission
GO:0007612 learning
GO:0035264 multicellular organism growth
GO:0040040 thermosensory behavior
GO:0042493 response to drug
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017740
View Gene Order
ENSBTAG00000014179
Not yet available
Pathways
NETPATH
REACTOME
REACT_19315
Cation-coupled Chloride cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21413
RefSeq NM_001134771 NM_020708
HUGO
OMIM
CCDS CCDS13391 CCDS46610
HPRD 09469
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca