Version 5.4
Bos taurus Gene: RHBDF2
Summary
InnateDB Gene IDBG-643037.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDF2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003436
Encoded Proteins
IDBP-695569
rhomboid 5 homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22550345
[Homo sapiens] RHBDF2 is required for the secretion of TNF in macrophages. (Demonstrated in mice)
PMID 22550345
[Mus musculus] Rhbdf2 is required for the secretion of Tnf in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129667:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55893571-55902692
Strand Forward strand
Band
Transcripts
ENSBTAT00000004463 ENSBTAP00000004463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129667
View Gene Order
ENSMUSG00000020806
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.2652
RefSeq XM_002696165 XM_005195850 XM_005195851 XM_005221303 XM_005221304 XM_596084
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca