InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGB4

Summary

InnateDB Gene

IDBG-643160.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB4

Gene Name

Integrin beta

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018169

Encoded Proteins

IDBP-695706

integrin, beta 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132470:
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:56472338-56506801

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000042566

ENSBTAP00000040201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007154	cell communication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0009611	response to wounding
GO:0031581	hemidesmosome assembly
GO:0046847	filopodium assembly
GO:0048870	cell motility

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome