InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGB4

Summary

InnateDB Gene

IDBG-68784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB4

Gene Name

integrin, beta 4

Synonyms

CD104

Species

Homo sapiens

Ensembl Gene

ENSG00000132470

Encoded Proteins

IDBP-68786

integrin, beta 4

IDBP-384514

integrin, beta 4

IDBP-384517

integrin, beta 4

IDBP-763071

IDBP-760202

IDBP-758049

IDBP-760597

IDBP-759862

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:75721328-75757818

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000200181	ENSP00000200181
ENST00000450894	ENSP00000405536
ENST00000449880	ENSP00000400217
ENST00000579662	ENSP00000463651
ENST00000584374
ENST00000582629	ENSP00000463788
ENST00000578318	ENSP00000462494
ENST00000584558
ENST00000580542
ENST00000584939	ENSP00000464259
ENST00000583327	ENSP00000464473
ENST00000579211
ENST00000584025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007154	cell communication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0009611	response to wounding
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0034329	cell junction assembly
GO:0046847	filopodium assembly
GO:0048870	cell motility

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome