InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC9A8

Summary

InnateDB Gene

IDBG-643194.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A8

Gene Name

Sodium/hydrogen exchanger

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008969

Encoded Proteins

IDBP-695743

solute carrier family 9 (sodium/hydrogen exchanger), member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197818:
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:78628908-78698768

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011809

ENSBTAP00000011809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015297	antiporter activity
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0015386	potassium:hydrogen antiporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0035725	sodium ion transmembrane transport
GO:0051453	regulation of intracellular pH
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport
GO:1902600	hydrogen ion transmembrane transport