Version 5.4
Bos taurus Gene: COPS4
Summary
InnateDB Gene IDBG-643214.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS4
Gene Name COP9 signalosome complex subunit 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006950
Encoded Proteins
IDBP-695757
COP9 signalosome complex subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138663:
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:99610792-99649394
Strand Forward strand
Band
Transcripts
ENSBTAT00000009128 ENSBTAP00000009128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138663
View Gene Order
ENSMUSG00000035297
View Gene Order
Cross-References
SwissProt Q3SZA0
TrEMBL
UniProt Splice Variant
Entrez Gene 540223
UniGene Bt.48928
RefSeq NM_001034694
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103017
GenPept AAI03018
RNA Seq Atlas 540223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca