InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.25715

Summary

InnateDB Gene

IDBG-643309.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25715

Gene Name

Uncharacterized protein

Synonyms

bmprii

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006420

Encoded Proteins

IDBP-695862

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204217:
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91395347-91461311

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008419

ENSBTAP00000008419

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001707	mesoderm formation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0002063	chondrocyte development
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009267	cellular response to starvation
GO:0009952	anterior/posterior pattern specification
GO:0010595	positive regulation of endothelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	regulation of lung blood pressure
GO:0016310	phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045906	negative regulation of vasoconstriction
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0060173	limb development
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061298	retina vasculature development in camera-type eye
GO:1902731	negative regulation of chondrocyte proliferation
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane