Version 5.4
| Bos taurus Gene: CPSF1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-643531.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | CPSF1 | ||||||||||
| Gene Name | Cleavage and polyadenylation specificity factor subunit 1 | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000008355 | ||||||||||
| Encoded Proteins |
Cleavage and polyadenylation specificity factor subunit 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071894:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 14:1728207-1742670 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
RNA Polymerase II Transcription pathway
Cleavage of Growing Transcript in the Termination Region pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
Processing of Capped Intronless Pre-mRNA pathway
mRNA 3'-end processing pathway
Transport of Mature Transcript to Cytoplasm pathway
RNA Polymerase II Transcription Termination pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Gene Expression pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Processing of Intronless Pre-mRNAs pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Processing of Intronless Pre-mRNAs pathway
mRNA 3'-end processing pathway
mRNA Splicing - Major Pathway pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Cleavage of Growing Transcript in the Termination Region pathway
RNA Polymerase II Transcription Termination pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
Processing of Capped Intronless Pre-mRNA pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA 3'-end processing pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Processing of Capped Intronless Pre-mRNA pathway
Processing of Intronless Pre-mRNAs pathway
RNA Polymerase II Transcription Termination pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
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| KEGG |
mRNA surveillance pathway pathway
mRNA surveillance pathway pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q10569 | ||||||||||
| TrEMBL | Q7YRA8 Q7YRA9 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 282703 | ||||||||||
| UniGene | Bt.4911 | ||||||||||
| RefSeq | NM_174720 XM_005215130 XM_005215131 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AJ518949 AJ518950 X83097 | ||||||||||
| GenPept | CAA58152 CAD58786 CAD58787 | ||||||||||
| RNA Seq Atlas | 282703 | ||||||||||