InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TAF6L

Summary

InnateDB Gene

IDBG-643673.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6L

Gene Name

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009484

Encoded Proteins

IDBP-696261

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162227:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:41785795-41793146

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012482

ENSBTAP00000012482

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0043966	histone H3 acetylation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity