Bos taurus Gene: RNF125 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-643709.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | RNF125 | ||||||||||
Gene Name | E3 ubiquitin-protein ligase RNF125 | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000003113 | ||||||||||
Encoded Proteins |
ring finger protein 125
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
InnateDB Annotation from Orthologs | |||||||||||
Summary |
[Homo sapiens] RNF125 is an ubiquitin ligase which negatively regulates RIG-I signalling by conjugating ubiquitin to DDX58 and MDA5 and IPS1, tagging them for proteosomal degradation
[Homo sapiens] RNF125 is inhibited by human Bocavirus protein, VP2, to induce the IFNB signalling pathway.
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Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101695:
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 24:25452969-25496186 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
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KEGG |
RIG-I-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Bt.51849 | ||||||||||
RefSeq | NM_001205859 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||