Version 5.4
Bos taurus Gene: RNF4
Summary
InnateDB Gene IDBG-643725.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF4
Gene Name E3 ubiquitin ligase RNF4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000027453
Encoded Proteins
IDBP-696304
RING finger protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063978:
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:108307673-108341783
Strand Reverse strand
Band
Transcripts
ENSBTAT00000039422 ENSBTAP00000039216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046685 response to arsenic-containing substance
GO:0090169 regulation of spindle assembly
GO:0090234 regulation of kinetochore assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000063978
View Gene Order
ENSMUSG00000029110
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6RV66
UniProt Splice Variant
Entrez Gene 617018
UniGene Bt.12878
RefSeq NM_001046589 XM_005208254 XM_005208255 XM_005208256 XM_005208257 XM_005208258
HUGO HGNC:10067
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018497
GenPept
RNA Seq Atlas 617018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca