InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF4

Summary

InnateDB Gene

IDBG-7539.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF4

Gene Name

ring finger protein 4

Synonyms

SLX5; SNURF

Species

Homo sapiens

Ensembl Gene

ENSG00000063978

Encoded Proteins

IDBP-7541

ring finger protein 4

IDBP-481820

ring finger protein 4

IDBP-482894

ring finger protein 4

IDBP-475288

ring finger protein 4

IDBP-480146

ring finger protein 4

IDBP-481662

ring finger protein 4

IDBP-478225

ring finger protein 4

IDBP-476142

ring finger protein 4

IDBP-475420

ring finger protein 4

IDBP-478595

ring finger protein 4

IDBP-479244

ring finger protein 4

IDBP-479604

ring finger protein 4

IDBP-475133

ring finger protein 4

IDBP-589195

ring finger protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:2462220-2625320

Strand

Forward strand

Band

p16.3

Transcripts

ENST00000314289	ENSP00000315212
ENST00000503659	ENSP00000423186
ENST00000504224	ENSP00000425667
ENST00000502316	ENSP00000423100
ENST00000509388
ENST00000507247	ENSP00000422728
ENST00000509258	ENSP00000422500
ENST00000511843
ENST00000504782
ENST00000513284	ENSP00000425724
ENST00000507784
ENST00000513578	ENSP00000422938
ENST00000511859	ENSP00000426615
ENST00000511892
ENST00000513643
ENST00000503123
ENST00000509206
ENST00000506706	ENSP00000424076
ENST00000511600	ENSP00000426503
ENST00000513450	ENSP00000422619
ENST00000508235	ENSP00000427212
ENST00000541204	ENSP00000446369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031491	nucleosome binding
GO:0032184	SUMO polymer binding
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030521	androgen receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046685	response to arsenic-containing substance
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination
GO:0090169	regulation of spindle assembly
GO:0090234	regulation of kinetochore assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029110

View Gene Order

ENSBTAG00000027453

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.740360

RefSeq

NM_001185009 NM_001185010 NM_002938

HUGO

OMIM

CCDS

CCDS47001 CCDS54713

HPRD

04167

IMGT

EMBL

GenPept

RNA Seq Atlas