InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.59584

Summary

InnateDB Gene

IDBG-643794.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.59584

Gene Name

cyclin-G-associated kinase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019188

Encoded Proteins

IDBP-696392

cyclin-G-associated kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178950:
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq, Jul 2008]
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the \'cyclin box.\' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:108988692-109036271

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025537

ENSBTAP00000025537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0009913	epidermal cell differentiation
GO:0016310	phosphorylation
GO:0035622	intrahepatic bile duct development
GO:0048468	cell development
GO:0048853	forebrain morphogenesis
GO:0061436	establishment of skin barrier
GO:0072318	clathrin coat disassembly
GO:0072583	clathrin-mediated endocytosis
GO:2000179	positive regulation of neural precursor cell proliferation