Version 5.4
Homo sapiens Gene: VIL1
Summary
InnateDB Gene IDBG-80992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIL1
Gene Name villin 1
Synonyms D2S1471; VIL
Species Homo sapiens
Ensembl Gene ENSG00000127831
Encoded Proteins
IDBP-80994
villin 1
IDBP-246323
villin 1
IDBP-388904
villin 1
IDBP-388905
villin 1
IDBP-388906
villin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218419092-218453295
Strand Forward strand
Band q35
Transcripts
ENST00000248444 ENSP00000248444
ENST00000392114 ENSP00000375962
ENST00000454069 ENSP00000412657
ENST00000440053 ENSP00000409270
ENST00000419986 ENSP00000394030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035727 lysophosphatidic acid binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0007010 cytoskeleton organization
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0009617 response to bacterium
GO:0010634 positive regulation of epithelial cell migration
GO:0030041 actin filament polymerization
GO:0030042 actin filament depolymerization
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0032233 positive regulation of actin filament bundle assembly
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051014 actin filament severing
GO:0051125 regulation of actin nucleation
GO:0051693 actin filament capping
GO:0060327 cytoplasmic actin-based contraction involved in cell motility
GO:0061041 regulation of wound healing
GO:0071364 cellular response to epidermal growth factor stimulus
GO:2000392 regulation of lamellipodium morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005902 microvillus
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032432 actin filament bundle
GO:0032433 filopodium tip
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026175
View Gene Order
ENSBTAG00000018543
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654595 Hs.707066
RefSeq NM_007127
HUGO
OMIM
CCDS CCDS2417
HPRD 01898
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca