InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STK36

Summary

InnateDB Gene

IDBG-643867.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK36

Gene Name

serine/threonine-protein kinase 36

Synonyms

fused-like

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003819

Encoded Proteins

IDBP-696472

serine/threonine kinase 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163482:
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:107356024-107382298

Strand

Forward strand

Band

Transcripts

ENSBTAT00000038254

ENSBTAP00000038069

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0003351	epithelial cilium movement
GO:0006468	protein phosphorylation
GO:0007228	positive regulation of hh target transcription factor activity
GO:0007420	brain development
GO:0009791	post-embryonic development
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity