InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STK36

Summary

InnateDB Gene

IDBG-81114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK36

Gene Name

serine/threonine kinase 36

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163482

Encoded Proteins

IDBP-81116

serine/threonine kinase 36

IDBP-246336

serine/threonine kinase 36

IDBP-388948

serine/threonine kinase 36

IDBP-388949

serine/threonine kinase 36

IDBP-388950

serine/threonine kinase 36

IDBP-388951

serine/threonine kinase 36

IDBP-388952

serine/threonine kinase 36

IDBP-388954

serine/threonine kinase 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:218672026-218702716

Strand

Forward strand

Band

q35

Transcripts

ENST00000295709	ENSP00000295709
ENST00000392105	ENSP00000375954
ENST00000455724	ENSP00000400055
ENST00000440309	ENSP00000394095
ENST00000424080	ENSP00000403527
ENST00000414413	ENSP00000406184
ENST00000422778	ENSP00000409688
ENST00000419433	ENSP00000404719
ENST00000468026
ENST00000473557
ENST00000470568
ENST00000480709
ENST00000492486
ENST00000486644
ENST00000473681
ENST00000462031

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0003351	epithelial cilium movement
GO:0006468	protein phosphorylation
GO:0007228	positive regulation of hh target transcription factor activity
GO:0007420	brain development
GO:0009791	post-embryonic development
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033276

View Gene Order

ENSBTAG00000003819

Not yet available

Pathways

NETPATH

NetPath_10

Hedgehog pathway

REACTOME

KEGG

hsa04340

Hedgehog signaling pathway pathway

hsa05217

Basal cell carcinoma pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.471404 Hs.712986

RefSeq

NM_001243313 NM_015690 XM_005246464

HUGO

OMIM

CCDS

CCDS2421 CCDS58750

HPRD

09631

IMGT

EMBL

GenPept

RNA Seq Atlas