InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.54995

Summary

InnateDB Gene

IDBG-644142.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.54995

Gene Name

E3 ubiquitin-protein ligase synoviolin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005076

Encoded Proteins

IDBP-696763

E3 ubiquitin-protein ligase synoviolin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162298:
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:43997381-44003325

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006699

ENSBTAP00000006699

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress