InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACSL3

Summary

InnateDB Gene

IDBG-644166.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL3

Gene Name

long-chain-fatty-acid--CoA ligase 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017258

Encoded Proteins

IDBP-696792

acyl-CoA synthetase long-chain family member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123983:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:111797170-111887224

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022939

ENSBTAP00000022939

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0008152	metabolic process
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042998	positive regulation of Golgi to plasma membrane protein transport
GO:0044539	long-chain fatty acid import
GO:0051047	positive regulation of secretion
GO:2001247	positive regulation of phosphatidylcholine biosynthetic process