Version 5.4
Bos taurus Gene: BT.55953
Summary
InnateDB Gene IDBG-644388.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.55953
Gene Name RB1-inducible coiled-coil protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000878
Encoded Proteins
IDBP-697024
RB1-inducible coiled-coil protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023287:
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23147992-23177073
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001169 ENSBTAP00000001169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0007254 JNK cascade
GO:0007507 heart development
GO:0010506 regulation of autophagy
GO:0043066 negative regulation of apoptotic process
GO:0045793 positive regulation of cell size
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0070969 ULK1-ATG13-FIP200 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000023287
View Gene Order
ENSMUSG00000025907
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.55953
RefSeq NM_001114155 XM_005215415
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca