InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SDCBP

Summary

InnateDB Gene

IDBG-644487.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDCBP

Gene Name

syntenin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019910

Encoded Proteins

IDBP-697132

syntenin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137575:
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:26412824-26447192

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026526

ENSBTAP00000026526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0045545	syndecan binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0042327	positive regulation of phosphorylation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005895	interleukin-5 receptor complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle