Version 5.4
Bos taurus Gene: ARFGEF1
Summary
InnateDB Gene IDBG-644666.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGEF1
Gene Name brefeldin A-inhibited guanine nucleotide-exchange protein 1
Synonyms BIG1
Species Bos taurus
Ensembl Gene ENSBTAG00000014691
Encoded Proteins
IDBP-697327
brefeldin A-inhibited guanine nucleotide-exchange protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066777:
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:33343880-33480413
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019553 ENSBTAP00000019553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0034237 protein kinase A regulatory subunit binding
Biological Process
GO:0007030 Golgi organization
GO:0010256 endomembrane system organization
GO:0030837 negative regulation of actin filament polymerization
GO:0032012 regulation of ARF protein signal transduction
GO:0034259 negative regulation of Rho GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0090284 positive regulation of protein glycosylation in Golgi
GO:0090303 positive regulation of wound healing
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030532 small nuclear ribonucleoprotein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000066777
View Gene Order
ENSMUSG00000067851
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BP90
UniProt Splice Variant
Entrez Gene 281022
UniGene Bt.4549
RefSeq NM_173997
HUGO HGNC:15772
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02038700 DAAA02038701 DAAA02038702 DAAA02038703 DAAA02038704 DAAA02038705 DAAA02038706 DAAA02038707
GenPept
RNA Seq Atlas 281022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca