InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAD9A

Summary

InnateDB Gene

IDBG-644689.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD9A

Gene Name

RAD9 homolog; Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012141

Encoded Proteins

IDBP-697344

RAD9 homolog

IDBP-697346

RAD9 homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172613:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3\' to 5\' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:45932454-45938364

Strand

Forward strand

Band

Transcripts

ENSBTAT00000044769	ENSBTAP00000042235
ENSBTAT00000016108	ENSBTAP00000016108

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0031573	intra-S DNA damage checkpoint
GO:0071479	cellular response to ionizing radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage