Version 5.4
Homo sapiens Gene: RAD9A
Summary
InnateDB Gene IDBG-60163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD9A
Gene Name RAD9 homolog A (S. pombe)
Synonyms RAD9
Species Homo sapiens
Ensembl Gene ENSG00000172613
Encoded Proteins
IDBP-60165
RAD9 homolog A (S. pombe)
IDBP-598491
RAD9 homolog A (S. pombe)
IDBP-586138
RAD9 homolog A (S. pombe)
IDBP-591303
RAD9 homolog A (S. pombe)
IDBP-809280
RAD9 homolog A (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3\' to 5\' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67317871-67398410
Strand Forward strand
Band q13.2
Transcripts
ENST00000307980 ENSP00000311360
ENST00000543808
ENST00000544620 ENSP00000444979
ENST00000538013 ENSP00000442064
ENST00000542139 ENSP00000445137
ENST00000541132
ENST00000530934
ENST00000529100
ENST00000535644
ENST00000622583
ENST00000621995 ENSP00000478994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 48 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000076 DNA replication checkpoint
GO:0000077 DNA damage checkpoint
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0031573 intra-S DNA damage checkpoint
GO:0071479 cellular response to ionizing radiation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0030896 checkpoint clamp complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024824
View Gene Order
ENSBTAG00000012141
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_828
G2/M Checkpoints pathway
REACT_115566
Cell Cycle pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655354
RefSeq NM_001243224 NM_004584 XM_006718652
HUGO
OMIM
CCDS CCDS8159
HPRD 04788
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca