Version 5.4
Bos taurus Gene: ACSL6
Summary
InnateDB Gene IDBG-644708.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSL6
Gene Name long-chain-fatty-acid--CoA ligase 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019708
Encoded Proteins
IDBP-697370
long-chain-fatty-acid--CoA ligase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164398:
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23779096-23882198
Strand Forward strand
Band
Transcripts
ENSBTAT00000008826 ENSBTAP00000008826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0007405 neuroblast proliferation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164398
View Gene Order
ENSMUSG00000020333
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_252780
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_255695
Fatty Acyl-CoA Biosynthesis pathway
REACT_237947
Triglyceride Biosynthesis pathway
KEGG
hsa00061
Fatty acid biosynthesis pathway
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04146
Peroxisome pathway
mmu03320
PPAR signaling pathway pathway
mmu00061
Fatty acid biosynthesis pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu00071
Fatty acid degradation pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q2TA22
UniProt Splice Variant
Entrez Gene 506059
UniGene Bt.11904
RefSeq NM_001038042 XM_005209031 XM_005209032 XM_005209033 XM_005209034
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111155 DAAA02019700 DAAA02019701 DAAA02019702 DAAA02019703 DAAA02019704 DAAA02019705 DAAA02019706 DAAA02019707 DAAA02019708
GenPept AAI11156
RNA Seq Atlas 506059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca