InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49626

Summary

InnateDB Gene

IDBG-644919.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49626

Gene Name

mRNA-decapping enzyme 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000767

Encoded Proteins

IDBP-697594

mRNA-decapping enzyme 2

IDBP-697597

mRNA-decapping enzyme 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172795:
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:944927-992564

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000065963	ENSBTAP00000054783
ENSBTAT00000049698	ENSBTAP00000046555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0050072	m7G(5')pppN diphosphatase activity

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006402	mRNA catabolic process
GO:0008152	metabolic process
GO:0071044	histone mRNA catabolic process