Version 5.4
Bos taurus Gene: LOX
Summary
InnateDB Gene IDBG-644978.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOX
Gene Name protein-lysine 6-oxidase precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012994
Encoded Proteins
IDBP-697655
protein-lysine 6-oxidase precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113083:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:33089540-33101644
Strand Forward strand
Band
Transcripts
ENSBTAT00000017275 ENSBTAP00000017275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004720 protein-lysine 6-oxidase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process
GO:0001568 blood vessel development
GO:0030199 collagen fibril organization
GO:0030324 lung development
GO:0048251 elastic fiber assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113083
View Gene Order
ENSMUSG00000024529
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_198996
Elastic fibre formation pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196515
Crosslinking of collagen fibrils pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.98817
RefSeq NM_173932 XM_005209102
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca