Version 5.4
Bos taurus Gene: SMPDL3B
Summary
InnateDB Gene IDBG-644979.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPDL3B
Gene Name acid sphingomyelinase-like phosphodiesterase 3b precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012997
Encoded Proteins
IDBP-697657
acid sphingomyelinase-like phosphodiesterase 3b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26095358
[Mus musculus] The membrane-modulating enzyme SMPDL3B is a negative regulator of TLR signalling that functions at the interface of membrane biology and innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130768:
Gene Information
Type Protein coding
Genomic Location Chromosome 2:125983558-126015376
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017279 ENSBTAP00000017279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006685 sphingomyelin catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130768
View Gene Order
ENSMUSG00000028885
View Gene Order
Cross-References
SwissProt
TrEMBL A6QQN6
UniProt Splice Variant
Entrez Gene 518699
UniGene Bt.63374
RefSeq NM_001100379
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149924 DAAA02006342
GenPept AAI49925
RNA Seq Atlas 518699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca