InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HSD17B4

Summary

InnateDB Gene

IDBG-644996.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B4

Gene Name

peroxisomal multifunctional enzyme type 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006978

Encoded Proteins

IDBP-697676

peroxisomal multifunctional enzyme type 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133835:
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:35662599-35763653

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009173

ENSBTAP00000009173

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0016508	long-chain-enoyl-CoA hydratase activity
GO:0042803	protein homodimerization activity
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001649	osteoblast differentiation
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0036111	very long-chain fatty-acyl-CoA metabolic process
GO:0036112	medium-chain fatty-acyl-CoA metabolic process
GO:0060009	Sertoli cell development