InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49134

Summary

InnateDB Gene

IDBG-645036.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49134

Gene Name

ubiquitin-like protein ATG12

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017525

Encoded Proteins

IDBP-697713

autophagy-related protein 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17921696

[Homo sapiens] ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

PMID 17921696

[Mus musculus] Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145782:
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:4619383-4799774

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023301

ENSBTAP00000023301

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019776	Atg8 ligase activity

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000422	mitochondrion degradation
GO:0006501	C-terminal protein lipidation
GO:0006995	cellular response to nitrogen starvation
GO:0044804	nucleophagy