InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARID1A

Summary

InnateDB Gene

IDBG-645115.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID1A

Gene Name

AT-rich interactive domain-containing protein 1A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001024

Encoded Proteins

IDBP-697804

AT rich interactive domain 1A (SWI-like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117713:
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:127000106-127066994

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001360

ENSBTAP00000001360

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0031491	nucleosome binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0003205	cardiac chamber development
GO:0003408	optic cup formation involved in camera-type eye development
GO:0006325	chromatin organization
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0030900	forebrain development
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060674	placenta blood vessel development

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0090544	BAF-type complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000117713

View Gene Order

ENSMUSG00000007880

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_202766

Chromatin modifying enzymes pathway

REACT_244207

RMTs methylate histone arginines pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.109821 Bt.21378

RefSeq

NM_001205785

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas