InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE8B

Summary

InnateDB Gene

IDBG-645173.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE8B

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020205

Encoded Proteins

IDBP-697866

phosphodiesterase 8B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113231:
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:8417822-8523989

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026909

ENSBTAP00000026909

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0035556	intracellular signal transduction
GO:0090032	negative regulation of steroid hormone biosynthetic process