InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FHIT

Summary

InnateDB Gene

IDBG-645176.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FHIT

Gene Name

Bis(5'-adenosyl)-triphosphatase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014418

Encoded Proteins

IDBP-697859

Bis(5'-adenosyl)-triphosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189283:
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
This gene, a member of the histidine triad gene family, encodes a diadenosine 5\',5\'\'\'-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:41319551-42108622

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019177

ENSBTAP00000019177

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0047710	bis(5'-adenosyl)-triphosphatase activity

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000189283

View Gene Order

ENSMUSG00000060579

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05223

Non-small cell lung cancer pathway

hsa00230

Purine metabolism pathway

hsa05222

Small cell lung cancer pathway

mmu05222

Small cell lung cancer pathway

mmu00230

Purine metabolism pathway

mmu05223

Non-small cell lung cancer pathway

INOH

PID NCI

Cross-References

SwissProt

Q1KZG4

TrEMBL

B6YY28 Q4KTA6

UniProt Splice Variant

Entrez Gene

692183

UniGene

Bt.26240

RefSeq

NM_001040646

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY862498 BC147993 DQ310176 DQ310177 DQ310178 DQ310179 DQ310181 DQ310182 DQ310183 DQ310184 DQ335870

GenPept

AAI47994 AAX55646 ABC61315 ABC61468 ABC61469 ABC61470 ABC61471 ABC68307 ABC68308 ABC68309 ABC68310

RNA Seq Atlas

692183