Version 5.4
Bos taurus Gene: DOK3
Summary
InnateDB Gene IDBG-645283.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK3
Gene Name docking protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025401
Encoded Proteins
IDBP-697988
docking protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22761938
[Homo sapiens] DOK3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages. (Demonstrated in mice)
PMID 22761938
[Mus musculus] Dok3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146094:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:40362436-40367515
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035679 ENSBTAP00000035549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146094
View Gene Order
ENSMUSG00000035711
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BD53
UniProt Splice Variant
Entrez Gene 514894
UniGene Bt.26129
RefSeq NM_001205324 XM_005209179 XM_005209180
HUGO HGNC:24583
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020056
GenPept
RNA Seq Atlas 514894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca