InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RUNX3

Summary

InnateDB Gene

IDBG-645327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX3

Gene Name

runt-related transcription factor 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019800

Encoded Proteins

IDBP-698030

runt-related transcription factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16164020

[Homo sapiens] RUNX3 is capable of activating the CD11a gene promoter that directs CD11a/CD18 integrin expression as well as trans-activating the CD49d gene promoter. The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provide co-stimulatory signals for the activation of T lymphocytes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000020633:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5\'-PYGPYGGT-3\' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:128629675-128656311

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026378

ENSBTAP00000026378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007411	axon guidance
GO:0031069	hair follicle morphogenesis
GO:0031175	neuron projection development
GO:0032609	interferon-gamma production
GO:0048469	cell maturation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000020633

View Gene Order

ENSMUSG00000070691

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1B8P0

UniProt Splice Variant

Entrez Gene

617389

UniGene

Bt.87217

RefSeq

NM_001193158

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02006404

GenPept

RNA Seq Atlas

617389