Bos taurus Gene: ITIH4
Summary
InnateDB Gene IDBG-645479.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH4
Gene Name inter-alpha-trypsin inhibitor heavy chain H4 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007850
Encoded Proteins
inter-alpha-trypsin inhibitor heavy chain H4 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000055955:
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:48615397-48630387
Strand Forward strand
Band
Transcripts
ENSBTAT00000010330 ENSBTAP00000010330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
GO:0034097 response to cytokine
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt
TrEMBL F1MMD7
UniProt Splice Variant
Entrez Gene 513700
UniGene Bt.5945
RefSeq NM_001015590
HUGO HGNC:6169
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054366
GenPept
RNA Seq Atlas 513700