Version 5.4
Homo sapiens Gene: SLC35A2
Summary
InnateDB Gene IDBG-64571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35A2
Gene Name solute carrier family 35 (UDP-galactose transporter), member A2
Synonyms CDG2M; CDGX; UDP-Gal-Tr; UGALT; UGAT; UGT; UGT1; UGT2; UGTL
Species Homo sapiens
Ensembl Gene ENSG00000102100
Encoded Proteins
IDBP-64573
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-64575
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-64577
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-64581
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-64583
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-370941
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-370942
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-370945
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-370953
solute carrier family 35 (UDP-galactose transporter), member A2
IDBP-807290
solute carrier family 35 (UDP-galactose transporter), member A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48903182-48911958
Strand Reverse strand
Band p11.23
Transcripts
ENST00000247138 ENSP00000247138
ENST00000376529 ENSP00000365712
ENST00000376521 ENSP00000365704
ENST00000376515 ENSP00000365698
ENST00000376512 ENSP00000365695
ENST00000445167 ENSP00000402726
ENST00000452555 ENSP00000416002
ENST00000413561 ENSP00000393233
ENST00000446885 ENSP00000415518
ENST00000616181 ENSP00000478617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005338 nucleotide-sugar transmembrane transporter activity
GO:0005351 sugar:proton symporter activity
GO:0005459 UDP-galactose transmembrane transporter activity
GO:0005515 protein binding
Biological Process
GO:0006012 galactose metabolic process
GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0015780 nucleotide-sugar transport
GO:0015785 UDP-galactose transport
GO:0015992 proton transport
GO:0055085 transmembrane transport
GO:0072334 UDP-galactose transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031156
View Gene Order
ENSBTAG00000002768
Not yet available
Pathways
NETPATH
REACTOME
REACT_22151
Transport of nucleotide sugars pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21899 Hs.733341
RefSeq NM_001032289 NM_001042498 NM_001282647 NM_001282648 NM_001282649 NM_001282650 NM_001282651 NM_005660
HUGO
OMIM
CCDS CCDS14311 CCDS35247 CCDS43937 CCDS65253 CCDS65254 CCDS75973 CCDS75974 CCDS75975
HPRD 02441
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca