Version 5.4
Bos taurus Gene: MAPKAPK3
Summary
InnateDB Gene IDBG-645782.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPKAPK3
Gene Name MAP kinase-activated protein kinase 3
Synonyms MAPKAP-K3; MK-3
Species Bos taurus
Ensembl Gene ENSBTAG00000016532
Encoded Proteins
IDBP-698529
MAP kinase-activated protein kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114738:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50281953-50310036
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021983 ENSBTAP00000021983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0044351 macropinocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114738
View Gene Order
ENSMUSG00000032577
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218381
Signalling to ERKs pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_207897
activated TAK1 mediates p38 MAPK activation pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_206069
Cellular responses to stress pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_213138
Immune System pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_215025
Cellular Senescence pathway
REACT_214419
Signalling to RAS pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_210984
p38MAPK events pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216714
Innate Immune System pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_227951
Signaling by VEGF pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_237946
activated TAK1 mediates p38 MAPK activation pathway
REACT_188820
Cellular Senescence pathway
REACT_239722
Signalling to RAS pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_207601
p38MAPK events pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_231290
Signalling to ERKs pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_248921
Signalling by NGF pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt Q3SYZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 615215
UniGene Bt.43984
RefSeq NM_001034779 XM_005222920
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103321 BT026197
GenPept AAI03322 ABG67036
RNA Seq Atlas 615215

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca