Mus musculus Gene: Mapkapk3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-197024.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mapkapk3 | ||||||||||||||||||||||
Gene Name | mitogen-activated protein kinase-activated protein kinase 3 | ||||||||||||||||||||||
Synonyms | 3PK; AI874665; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3; MK3 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000032577 | ||||||||||||||||||||||
Encoded Proteins |
mitogen-activated protein kinase-activated protein kinase 3
mitogen-activated protein kinase-activated protein kinase 3
mitogen-activated protein kinase-activated protein kinase 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114738:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:107254927-107289877 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Cellular Senescence pathway
Signalling to RAS pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
p38MAPK events pathway
VEGFA-VEGFR2 Pathway pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
VEGF signaling pathway pathway
MAPK signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
activated TAK1 mediates p38 MAPK activation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
p38MAPK events pathway
Signalling to RAS pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by VEGF pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Signalling to ERKs pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cellular responses to stress pathway
VEGFA-VEGFR2 Pathway pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Cellular Senescence pathway
Signalling to RAS pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Signalling by NGF pathway
Signaling by VEGF pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
p38MAPK events pathway
MyD88 dependent cascade initiated on endosome pathway
Innate Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
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KEGG |
VEGF signaling pathway pathway
MAPK signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
Signaling mediated by p38-alpha and p38-beta
p38 signaling mediated by MAPKAP kinases
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B0QZU6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 102626 | ||||||||||||||||||||||
UniGene | Mm.222612 Mm.445242 | ||||||||||||||||||||||
RefSeq | NM_178907 XM_006511616 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS23487 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:2143163 | ||||||||||||||||||||||
MGI Symbol | Mapkapk3 | ||||||||||||||||||||||
EMBL | AL672070 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 102626 | ||||||||||||||||||||||