InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC12A6

Summary

InnateDB Gene

IDBG-646104.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A6

Gene Name

solute carrier family 12 member 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016236

Encoded Proteins

IDBP-698881

solute carrier family 12 (potassium/chloride transporters), member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140199:
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:28357075-28439037

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021604

ENSBTAP00000021604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015079	potassium ion transmembrane transporter activity
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding
GO:0035827	rubidium ion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0010107	potassium ion import
GO:0035826	rubidium ion transport
GO:0055085	transmembrane transport
GO:0071476	cellular hypotonic response
GO:0071477	cellular hypotonic salinity response
GO:1902476	chloride transmembrane transport