InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64311

Summary

InnateDB Gene

IDBG-646321.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64311

Gene Name

ubiquitin-like modifier-activating enzyme ATG7 isoform 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000035827

Encoded Proteins

IDBP-699116

APG7 autophagy 7-like isoform 1

IDBP-699119

APG7 autophagy 7-like isoform 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25512546

[Mus musculus] Atg7 plays an essential role for autophagy during invariant natural killer T cell development.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197548:
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:55944219-56217921

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043980	ENSBTAP00000041507
ENSBTAT00000050314	ENSBTAP00000047028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019778	Atg12 activating enzyme activity
GO:0019779	Atg8 activating enzyme
GO:0042803	protein homodimerization activity

Biological Process

GO:0000422	mitochondrion degradation
GO:0001889	liver development
GO:0006497	protein lipidation
GO:0006501	C-terminal protein lipidation
GO:0006520	cellular amino acid metabolic process
GO:0006914	autophagy
GO:0006995	cellular response to nitrogen starvation
GO:0006996	organelle organization
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0009267	cellular response to starvation
GO:0009791	post-embryonic development
GO:0010508	positive regulation of autophagy
GO:0016236	macroautophagy
GO:0016239	positive regulation of macroautophagy
GO:0016567	protein ubiquitination
GO:0021680	cerebellar Purkinje cell layer development
GO:0021860	pyramidal neuron development
GO:0021955	central nervous system neuron axonogenesis
GO:0021987	cerebral cortex development
GO:0030163	protein catabolic process
GO:0031175	neuron projection development
GO:0031396	regulation of protein ubiquitination
GO:0031401	positive regulation of protein modification process
GO:0032446	protein modification by small protein conjugation
GO:0034727	piecemeal microautophagy of nucleus
GO:0039689	negative stranded viral RNA replication
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044805	late nucleophagy
GO:0045732	positive regulation of protein catabolic process
GO:0050877	neurological system process
GO:0055013	cardiac muscle cell development
GO:0061024	membrane organization
GO:0071455	cellular response to hyperoxia