InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GABRB2

Summary

InnateDB Gene

IDBG-646438.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRB2

Gene Name

gamma-aminobutyric acid receptor subunit beta-2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018585

Encoded Proteins

IDBP-699243

gamma-aminobutyric acid (GABA) A receptor, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145864:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:75103433-75393342

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024736

ENSBTAP00000024736

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007605	sensory perception of sound
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0090102	cochlea development
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome