Version 5.4
Bos taurus Gene: GABRG2
Summary
InnateDB Gene IDBG-646441.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRG2
Gene Name gamma-aminobutyric acid receptor subunit gamma-2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010251
Encoded Proteins
IDBP-699249
gamma-aminobutyric acid receptor subunit gamma-2 precursor
IDBP-699250
gamma-aminobutyric acid receptor subunit gamma-2 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113327:
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:75895256-76022776
Strand Forward strand
Band
Transcripts
ENSBTAT00000013543 ENSBTAP00000013543
ENSBTAT00000066231 ENSBTAP00000054701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0009791 post-embryonic development
GO:0030534 adult behavior
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113327
View Gene Order
ENSMUSG00000020436
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_198560
GABA A receptor activation pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_268398
Orphan transporters pathway
REACT_198558
Ligand-gated ion channel transport pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_224131
GABA receptor activation pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0JN66 F1MIG7 G3MYR4
UniProt Splice Variant
Entrez Gene 282240
UniGene
RefSeq NM_174545 XM_005209697
HUGO HGNC:4087
OMIM
CCDS
HPRD
IMGT
EMBL BC126536 DAAA02020916 DAAA02020917
GenPept AAI26537
RNA Seq Atlas 282240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca