InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.41314

Summary

InnateDB Gene

IDBG-646498.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.41314

Gene Name

ras-related protein Rab-7a

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010193

Encoded Proteins

IDBP-699309

ras-related protein Rab-7a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075785:
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:59862214-59877343

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013451

ENSBTAP00000013451

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006622	protein targeting to lysosome
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007174	epidermal growth factor catabolic process
GO:0007264	small GTPase mediated signal transduction
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0045022	early endosome to late endosome transport
GO:0090383	phagosome acidification
GO:0090385	phagosome-lysosome fusion

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome