Version 5.4
| Bos taurus Gene: RGMB | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-646600.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | RGMB | ||||||||
| Gene Name | Uncharacterized protein | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000011864 | ||||||||
| Encoded Proteins |
RGM domain family, member B
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] RGMB is highly expressed in macrophages and negatively regulates IL6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway. (Demonstrated in murine model)
[Mus musculus] Rgmb is highly expressed in macrophages and negatively regulates Il6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174136:
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:100425877-100446422 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Netrin-1 signaling pathway
Developmental Biology pathway
Axon guidance pathway
Netrin-1 signaling pathway
Axon guidance pathway
Developmental Biology pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MFY9 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 540954 | ||||||||
| UniGene | Bt.105463 | ||||||||
| RefSeq | XM_002689413 XM_613847 | ||||||||
| HUGO | HGNC:26896 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02021391 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 540954 | ||||||||