InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: USP8

Summary

InnateDB Gene

IDBG-646665.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP8

Gene Name

ubiquitin carboxyl-terminal hydrolase 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011916

Encoded Proteins

IDBP-699489

ubiquitin carboxyl-terminal hydrolase 8

IDBP-699490

ubiquitin carboxyl-terminal hydrolase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138592:
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:59984279-60037841

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033814	ENSBTAP00000033723
ENSBTAT00000015809	ENSBTAP00000015809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007032	endosome organization
GO:0007265	Ras protein signal transduction
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody