InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC27A2

Summary

InnateDB Gene

IDBG-646670.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A2

Gene Name

very long-chain acyl-CoA synthetase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004303

Encoded Proteins

IDBP-699495

solute carrier family 27 (fatty acid transporter), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140284:
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:60221115-60275998

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005640

ENSBTAP00000005640

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005102	receptor binding
GO:0015245	fatty acid transporter activity
GO:0019899	enzyme binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0050197	phytanate-CoA ligase activity
GO:0070251	pristanate-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001561	fatty acid alpha-oxidation
GO:0001676	long-chain fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0015908	fatty acid transport
GO:0042760	very long-chain fatty acid catabolic process
GO:0044539	long-chain fatty acid import
GO:0097089	methyl-branched fatty acid metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome