Version 5.4
Bos taurus Gene: PPM1A
Summary
InnateDB Gene IDBG-646747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1A
Gene Name Protein phosphatase 1A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018127
Encoded Proteins
IDBP-699578
Protein phosphatase 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100614:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72757582-72768778
Strand Forward strand
Band
Transcripts
ENSBTAT00000024128 ENSBTAP00000024128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004871 signal transducer activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070412 R-SMAD binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006499 N-terminal protein myristoylation
GO:0007165 signal transduction
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100614
View Gene Order
ENSMUSG00000021096
View Gene Order
Pathways
NETPATH
REACTOME
REACT_206974
Insulin receptor signalling cascade pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_213280
PKB-mediated events pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_216992
mTOR signalling pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_208835
IRS-related events pathway
REACT_226022
Gene Expression pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_209911
PI3K Cascade pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_223827
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_209268
Regulation of AMPK activity via LKB1 pathway
REACT_203853
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_221246
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_456
PKB-mediated events pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_220701
Regulation of AMPK activity via LKB1 pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_204167
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_220566
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_240139
PI3K Cascade pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_243154
IRS-related events pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_242206
IRS-mediated signalling pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_255725
mTOR signalling pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_256714
PKB-mediated events pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
bmppathway
BMP receptor signaling
smad2_3pathway
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cross-References
SwissProt O62829
TrEMBL
UniProt Splice Variant
Entrez Gene 782038
UniGene Bt.4671 Bt.68991
RefSeq NM_174429 XM_001250611 XM_002686315
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ005457
GenPept CAA06554
RNA Seq Atlas 281994 782038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca